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MIDxPRO: MIcrowave Diagnosis of Breast Cancer with Open Ended Contact PRObes

 

Project description:

This action proposes to carry out research in open ended contact probe (OECP) technique to lay out foundation work for development of two new applications: an automated surgical margin detection device for breast cancer treatment and an automated microwave biopsy probe for breast cancer diagnosis. While the envisioned applications require a single and highly accurate measurement, OECP technique suffers from high error and low repeatability dielectric property measurements. The error mostly stems from the current mathematical approach utilized for the dielectric property retrieval which may converge to local minimum and can magnify the measurement set-up based errors. This research will first target the existing error by proposing robust mathematical retrieval approaches. Next, application based modifications will be investigated with new probe structures. Finally, further error minimization will be achieved by introducing classification algorithms. Developed techniques will be validated with animal experiments. The outcomes of this research will greatly contribute to the innovation of new medical devices that can be utilized for breast cancer, representing one of the most commonly diagnosed cancer type among women. The researcher is well-equipped and has the required capabilities to execute the objectives of this research. The host organization and supervisors have an extensive track record in medical device development, necessary infrastructure, network, and expertise. This research will allow the researcher to become independent by extending her network, publication/grant track record, skill sets, and more importantly, through joining an innovation oriented host organization, the researcher will gain expertise in phases that enables the research to be transformed into innovation. Finally, the goal of the proposed research, building the foundation for innovation, is also in line with ‘Future and Emerging Technologies’ call of the H2020 work program.

more project info on Cordis MIDXPRO youtube channel

 

Journal publications:

  • Nural Pastaci Ozsobaci, Fatma Ates Alkan, Tuba Yilmaz, ‘Multiclass Classification of Rat Mammary Tissues’, IEEE Access (To be submitted)
  • Tuba Yilmaz, ‘Microwave Dielectric Properties of Rat Mammary Tissues and Carcinoma from 500 MHz to 18 GHz.’ Sensors, Multi Diciplinary Publishing Institute (MDPI)(To be Submitted)
  • Emre Onemli, Sulayman Joof, Cemanur Aydinalp, Sultan Onemli, Nural Pastaci Ozsobaci, Fatma Ates Alkan, Nuray Kepil, Islem Rekik, Ibrahim Akduman, and Tuba Yilmaz, ‘Towards Microwave Diagnostic Pathology: on the Classification of Rat Mammary Carcinoma with a Large Scale in vivo Microwave Measurement.’ Brief Reports, Proceedings of the National Academy of Sciences of the United States of America (PNAS). (To be Submitted)
  • Ismail Dilman, Mehmet Nuri Akinci, Tuba Yilmaz and Mehmet Cayoren, ‘Debye Parameter Based Complex Dielectric Permittivity Retrieval with Open-Ended Coaxial Probes.’ IEEE Transactions on Microwave Theory and Techniques. (To be Submitted)
  • Tuba Yilmaz, Banu Saçlı, Cemanur Aydınalp, Gökhan Cansız, Sulayman Joof, Mehmet Çayören, Bülent Önal, and Ibrahim Akduman. " Microwave dielectric spectroscopy of renal calculi: A large scale study on dielectric properties from 500 MHz to 18 GHz." IEEE Transactions on Dielectrics and Electrical Insulation (2019) (Expected publication: October Issue).
  • Banu Saçlı, Cemanur Aydınalp, Gökhan Cansız, Sulayman Joof, Tuba Yilmaz, Mehmet Çayören, Bülent Önal, and Ibrahim Akduman. "Microwave dielectric property based classification of renal calculi: Application of a kNN algorithm."Computers in biology and medicine 112 (2019): 103366. PDF LINK
  • Tuba Yilmaz, Robert Foster, and Yang Hao. "Radio-frequency and microwave techniques for non-invasive measurement of blood glucose levels." Diagnostics 9.1 (2019): 6. LINK

 

Conference publications:

  • Sulayman Joof, Gokhan Cansiz, Selcuk Ozgur, Tuba Yilmaz, Mehmet Cayoren, and Ibrahim Akduman. "Tissue Mimicking Phantoms for Microwave Brain Stroke Imaging." In 2018 18th Mediterranean Microwave Symposium (MMS), pp. 332-333. IEEE. PDF LINK
  • Tuba Yilmaz, "Towards Optimization of Open Ended Contact Probes for Breast Cancer Diagnosis." 2018 Progress in Electromagnetics Research Symposium (PIERS-Toyama). IEEE, 2018. PDF LINK
  • Cemanur Aydinalp, Sulayman Joof, Tuba Yilmaz, Nural Pastaci Özsobaci, Fatma Ateş Alkan, and Ibrahim Akduman. "In Vitro Dielectric Properties of Rat Skin Tissue for Microwave Skin Cancer Detection." In 2019 International Applied Computational Electromagnetics Society Symposium (ACES), pp. 1-2. IEEE, 2019. PDF LINK
  • Cemanur Aydinalp, Sulayman Joof, Ibrahim Akduman, and Tuba Yilmaz, " Sensitivity and Sensing Depth Analysis of Open-ended Contact Probes for Cancer Diagnosis." 2019 Progress in Electromagnetics Research Symposium (PIERS-Rome). IEEE, 2019.(To be published) to be published
  • Cemanur Aydinalp, Sulayman Joof, and Tuba Yilmaz, " Sensing Depth Analysis of Open-Ended Coaxial Probe for Skin Cancer Detection" 23rd International Conference on Applied Electromagnetics and Communications (ICECOM-Dubrovnik), 2019. (To be published) to be published
  • Zeynep Macit, Cemanur Aydinalp, Ayşe Buse Ozdabak Sert, Fatma Nese Kok, and Tuba Yilmaz, " Microwave Dielectric properties of Osteosarcoma Cell Line (SAOS-2) Suspensions." 23rd International Conference on Applied Electromagnetics and Communications (ICECOM-Dubrovnik), 2019. (To be published) to be published
  • Tuba Yilmaz, Nural Pastaci Ozsobaci, Fatma Ates Alkan, Nuray Kepil, Ibrahim Akduman, " In-vivo microwave dielectric properties of healthy and carcinogenic rat nasal tissues from 500 MHz to 6 GHz." 2019 IEEE Conference on Antenna Measurement and Applications (2019 IEEE CAMA), 2019. (To be published) to be published

 

Project progress:

WP1 Project Management
100%
WP2 Training and Transfer of Knowledge
100%
WP3 Developement of Dielectic Property Retrival Algorithm
100%
WP4 Developement and Testing of Probes
100%
WP5 Developement and Testing of Classification Algorithms
100%
WP6 Dissemination and Communication
100%

 

Dissemination and other activities: